Calcium l-threonate for preventing or treating bone fracture

Details Calcium l-threonate for preventing or treating bone fracture Calcium l-threonate for preventing or treating bone fracture

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/00 (2006.01) A61K 31/198 (2006.01)

Patent

CA 2471232

The present invention relates to calcium L-threonate compound for preventing or treating bone fracture, a composition comprising the same and use of the same. It had been found from experiments that calcium L-threonate could not only promote proliferation, differentiation and mineralization of osteoblast, but also could promote the expression of collager I mRNA of osteoblast culturedin vitro. Accordingly it facilitated bone fracture healing, increased bone density and mechanical performance, so as to prevent or treat bone fracture.

L'invention concerne un composé de L-thréonate de calcium pour la prévention ou le traitement de fractures osseuses, une composition renfermant ce composé ainsi que son utilisation. Les expériences ont montré que le L-thréonate de calcium peut non seulement favoriser la prolifération, la différenciation et la minéralisation de l'ostéoblaste, mais aussi l'expression de l'ARNm du type collagène 1 de l'ostéoblaste cultivé in vitro. Il facilite donc la guérison des fractures osseuses, accroît la densité osseuse et la performance mécanique de façon à prévenir ou à traiter des fractures osseuse.

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