Calcium phosphate artificial bone as osteoconductive and...

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61F 2/28 (2006.01) A61L 24/02 (2006.01) A61L 27/12 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2401194

The present invention relates to a novel calcium phosphate artificial bone promotive of biocompatible osteoanagenesis, which comprises an ordinary calcium phosphate bone cement and a linear polyphosphate. The linear polyphosphate of the calcium phosphate artificial bone comprises 3-200 orthophosphate molecules and is used in an amount of 0.001-0.05 % by weight based on the total weight of the calcium phosphate artificial bone. The polyphosphate-containing artificial bone of the present invention is non-toxic to the body and chemically stable, and economically favorable in terms of production cost with superior biodegradability. Thus, the polyphosphate-containing artificial bone of the present invention can replace as osteoconductive and osteoinductive, biodegradable substitute for a conventional bone cements,allografts and autografts which are used in the treatment of defects and fractures in every bone of the body, the cure of osteoporous, the fillers of implant for dental surgery, the bone substitute for plastic surgery, the substitution of defected bones in the operation on joints, including hip-joint, knee-joint and shoulder joint, and the operation on the vertabra.

L'invention concerne un os artificiel en phosphate de calcium favorisant l'ostéoanagenèse biocompatible, qui comprend un ciment d'os en phosphate de calcium ordinaire et un polyphosphate linéaire, ce dernier comprenant lui-même entre 3 et 200 molécules d'orthophosphate et représentant, en poids, entre 0,001 et 0,05 % du poids total. Il s'agit d'un produit non toxique pour le corps, chimiquement stable, rentable à la production et présentant une biodégradabilité supérieure. Ce type d'os peut donc être un substitut ostéoconducteur, ostéoinducteur et biodégradable pour type conventionnel de ciment d'os, d'allogreffe et d'autogreffe propre au traitement des défauts et fractures d'os quelconque du corps, de l'ostéoporose, et pour la matière de remplissage des implants dentaires, la substitution osseuse en chirurgie plastique, ou le remplacement d'os défectueux dans les opérations de la hanche, y compris l'articulation de la hanche, mais aussi dans les opérations relatives à l'articulation du genou et de l'épaule et les opérations relatives aux vertèbres.

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