A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
167/326
A61L 27/00 (2006.01) A61F 2/28 (2006.01) A61L 27/12 (2006.01) C01B 25/32 (2006.01) A61F 2/00 (2006.01)
Patent
CA 1297039
CALCIUM PHOSPHATE BONE SUBSTITUTE MATERIALS ABSTRACT OF THE DISCLOSURE Calcium phosphates useful as bone substitute materi- al or for the manufacture of prosthetic devices have been prepared from calcium hydroxyapatite material which has a uniformly permeable microporous structure chacter- ized by a substantially uniform pore volume in the range from about 10 to about 90% and by a pronounced three- dimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material of marine life by reacting said calcium hydroxyapatite material which has a calcium to phosphorus atomic ratio of about 1.66 with a phosphate-contributing or phosphorus-contributing moiety or with a calcium-contributing or calcium oxide- contributing moiety so as to alter the calcium to phos- phorus Ca/P atomic ratio to yield a calcium phosphate material retaining the above-described microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material but having a calcium to phosphorus Ca/P atomic ratio less than or greater than 1.6, such as a calcium phosphate material comprising dicalcium phos- phate and/or tricalcium phosphate and having a calcium to phosphorus Ca/P atomic ratio in the range 1.0 1.5 when the calcium hydroxyapatite material is reacted with said phosphate-contributing or phosphorus-contributing moiety or a calcium phosphate material having a calcium to phosphorus Ca/P atomic ratio greater than 1.66 up to 2.0 when the calcium hydroxyapatite material is reacted with said calcium-contributing or calcium oxide-contrib- uting moiety and comprising tetracalcium phosphate.
558717
Cassan Maclean
Interpore International
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