Calcium phosphate hydroxyapatite precursor and methods for...

A - Human Necessities – 61 – K

Patent

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A61K 6/033 (2006.01) A61K 8/24 (2006.01) A61L 24/02 (2006.01) A61L 27/00 (2006.01) A61L 27/12 (2006.01) A61Q 11/00 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2157890

Calcium phosphate composition that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.

L'invention concerne des compositions originales de phosphate de calcium qui sont particulièrement utiles en orthopédie et en dentisterie comme ciment et comme agent de reminéralisation, des procédés et des systèmes prêts à l'emploi pour leur utilisation, ainsi que les produits obtenus. Les compositions sont constituées de phosphate de tétracalcium préparé à partir d'un mélange avec un rapport calcium/phosphate inférieur à 2, ou préparé et conservé dans des conditions essentiellement anhydres avant l'utilisation ou, de préférence, elles satisfont à ces deux critères. Les nouvelles compositions sont converties essentiellement en hydroxyapatite au cours du durcissement, elles sont résorbées graduellement et remplacées par de l'os lorsqu'elles sont implantées en contact avec un tissu osseux vivant et elles offrent des avantages nets en termes de solidité du ciment, du temps du durcissement, de fiabilité et d'autres propriétés.

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