C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A23L 1/304 (2006.01) A61K 8/34 (2006.01) A61K 38/16 (2006.01) A61P 19/10 (2006.01) A61Q 11/00 (2006.01) C07K 7/06 (2006.01) C01B 25/32 (2006.01)
Patent
CA 2283680
Phosphopeptides containing the Ser(P) cluster sequence motif Ser(P)-Ser(P)- Ser(P)-Glu-Glu- can stabilise their own weight in amorphous calcium phosphate (ACP) [Ca3(PO4)1.87(HPO4)0.2xH2O] and amorphous calcium fluoride phosphate (ACFP) [Ca8(PO4)5 F x H2O]. The amorphous phases stabilised by the phosphopeptides are an excellent delivery vehicle to co-localise Ca, F, and phosphate at the tooth surface in a slow-release amorphous form producing superior anticaries efficacy. These amorphous phases stabilised by the phosphopeptides also have utility as dietary supplements to increase calcium bioavailability and to help prevent diseases associated with calcium deficiencies.
Les phosphopeptides contenant le motif de séquence à groupes de Ser(P), Ser(P)-Ser(P)-Ser(P-)Glu-Glu-, peuvent stabiliser leur propre poids dans le phosphate de calcium amorphe (PCA) [CA¿3?(PO¿4?)¿1,87?(HPO¿4?)¿0,2?xH¿2?O] et le phosphate de fluorure de calcium amorphe (PFCA) [Ca¿8?(PO¿4?)¿5? F x H¿2?O]. Les phases amorphes stabilisées par les phosphopeptides constituent un excellent véhicule de libération pour la co-localisation de Ca, F et du phosphate à la surface des dents, sous forme amorphe à libération lente, ayant une efficacité anti-carie supérieure. Ces phases amorphes stabilisées par les phosphopeptides ont également une utilité en tant que compléments alimentaires pour l'augmentation de la biodisponibilité du calcium et pour aider à la prévention de maladies associées aux carences calciques.
Kirby Eades Gale Baker
The University Of Melbourne
Victorian Dairy Industry Authority
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