C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/25 (2006.01) A61K 31/145 (2006.01) A61K 31/395 (2006.01) C07C 217/18 (2006.01) C07C 217/20 (2006.01) C07D 209/08 (2006.01) C07D 263/58 (2006.01) C07D 277/74 (2006.01)
Patent
CA 2259922
Novel calcium receptor-active compounds represented by the following general formula: Ar1-[CR1R2]p-X-[CR3R4]q-[CR5R6]-NR7 -[CR8R9]-Ar2 wherein Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroaryl-methyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R1, R2, R3, R4, R5, R6, R7, R8 and R9 represent, for example, each hydrogen or alkyl; Ar2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6; and q is an integer of from 0 to 14.
La présente invention concerne des composés actifs comme récepteurs du calcium représentés par la formule générale: Ar1-[CR<1>R<2>]p-X-[CR<3>R<4>]q-[CR<5>R<6>]-NR<7>-[CR<8>R<9>]-Ar2. Dans cette formule générale, Ar1 appartient au groupe des aryl, hétéroaryl, bis(arylméthyl)amino, bis(hétéroaryl-méthyl)amino, et arylméthyl(hétéroarylméthyl)amino. X appartient au groupe des oxygène, soufre, sulfinyl, sulfonyl, carbonyl et amino. R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> et R<9> représentent chacun par exemple un hydrogène ou alkyl. Ar2 appartient au groupe des aryl et hétéroaryl. "p" est un entier valant de 0 à 6, "q" étant un entier valant de 0 à 14.
Sakai Teruyuki
Suzuki Rika
Takami Atsuya
Kirin Beer Kabushiki Kaisha
Kyowa Hakko Kirin Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Nps Pharmaceuticals Inc.
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