Calcium receptor antagonists

Details Calcium receptor antagonists Calcium receptor antagonists

C - Chemistry, Metallurgy

07

C

C07C 217/10 (2006.01) A61K 31/135 (2006.01) A61K 31/18 (2006.01) A61K 31/275 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/426 (2006.01) A61K 31/4402 (2006.01) C07C 217/28 (2006.01) C07C 217/60 (2006.01) C07C 217/76 (2006.01) C07C 229/38 (2006.01) C07C 233/25 (2006.01) C07C 235/42 (2006.01) C07C 235/60 (2006.01) C07C 237/30 (2006.01) C07C 255/54 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07D 213/30 (2006.01) C07D 277/24 (2006.01) C07D 307/42 (2006.01) C07D 317/58 (2006.01) C07D 3

Patent

CA 2418794

A compound of the formula [I] (see formula I) wherein R2 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 cycloalkyl group and the like; R3 is hydrogen atom, C1-6 alkyl group, hydroxyl group and the like; R4 is hydrogen atom, C1-6 alkyl group and the like; R5 and R6 are each C1-6 alkyl group and the like; R7 is optionally substituted aryl group or optionally substituted heteroaryl group; X1, X2 and X3 are each C1-6 alkylene group and the like; and X4 and X5 are each a single bond, methylene group and the like, a salt thereof, a solvate thereof or a prodrug thereof, and a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic agent for osteoporosis, are provided. The compound of the present invention is useful as a therapeutic drug of diseases accompanied by abnormal calcium homeostasis, or osteoporosis, hypoparathyreosis, osteosarcoma, periodontal disease, bone fracture, steoarthrosis, chronic rheumatoid arthritis, Paget's disease, humoral hypercalcemia, autosomal dominant hypocalcemia and the like. In addition, an intermediate for the compound is provided.

L'invention concerne des composés représentés par la formule (I), des sels ou des solvates de ces derniers ainsi que des précurseurs de médicament; des compositions pharmaceutiques (comprenant des antagonistes du récepteur de calcium) contenant lesdits composés, sels, solvates ou précurseurs de médicament; et des intermédiaires desdits composés, sels, solvates et précurseurs de médicament. Dans la formule, R<1> représente aryle éventuellement substitué ou analogue ; R<2> représente alkyle C1-6 éventuellement substitué ou analogue; R<3> représente hydrogène ou analogue; R<4> représente hydrogène ou analogue; R5 et R<6> représentent chacun alkyle C1-6 ou analogue; R<7> représente aryle éventuellement substitué ou analogue; X<1>, X<2> et X<3> représentent chacun alkylène C1-6 ou analogue; et X<4> et X<5> représentent chacun une liaison simple ou analogue. Formule (I)

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