C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/12 (2006.01) C07D 209/08 (2006.01) C07D 209/10 (2006.01) C07D 209/80 (2006.01) C07D 209/86 (2006.01) C07D 209/88 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 249/04 (2006.01) C07D 249/18 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2485685
The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
La présente invention a trait à des composés de structure générale (I) ou un de ses sels pharmaceutiquement acceptables, et des compositions les contenant, dans lesquels les variables sont tels que définis dans la description, et dont l'utilisation réduit ou inhibe la sécrétion de l'hormone parathyroïde (PTH), comprenant des procédés permettant la réduction ou l'inhibition de la sécrétion de PTH et des procédés de traitement ou de prophylaxie de maladies liées à des troubles de l'os, telles que l'ostéoporose, ou liées à l'excès de sécrétion de PTH, telles que l'hyperparathyroïdisme. L'invention a trait également à des procédés permettant la fabrication de tels composés ainsi que des intermédiaires utiles dans de tels procédés.
Coulter Thomas S.
Ghiron Chiara
Kelly Michael G.
Semin David J.
Townsend Robert
Amgen Inc.
Gowling Lafleur Henderson Llp
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