C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/58 (2006.01) A61K 31/137 (2006.01) A61K 31/167 (2006.01) A61K 31/404 (2006.01) A61K 31/423 (2006.01) A61K 31/426 (2006.01) A61K 31/4418 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) A61P 3/14 (2006.01) A61P 5/18 (2006.01) A61P 19/10 (2006.01) C07C 211/27 (2006.01) C07C 211/29 (2006.01) C07C 211/30 (2006.01) C07C 217/54 (2006.01) C07C 233/18 (2006.01) C07C 233/43 (2006.01) C07C 235/20 (2006.01) C07C 237/30 (2006.01) C07C 255/58 (2006.01) C07C 255/59 (2006.01) C07C 275/40 (2006.01) C07C 311/0
Patent
CA 2486399
The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
L'invention concerne des composés de structure générale (I) : (I) ou un sel acceptable sur le plan pharmaceutique de ceux-ci, ainsi que des compositions renfermant ces composés, les variables étant définis dans la description, et l'utilisation desdits composés aux fins de diminution ou d'inhibition de la sécrétion de PTH, notamment des procédés de diminution ou d'inhibition de la sécrétion de PTH et des méthodes de traitement ou de prophylaxie de maladies associées à des troubles osseux, tels que l'ostéoporose ou des maladies associées à une sécrétion excessive de PTH, telles que l'hyperparathyroïdisme. L'invention concerne enfin des procédés de fabrication de tels composés, ainsi que des intermédiaires utiles dans de tels procédés.
Coulter Thomas S.
Ghiron Chiara
Kelly Michael G.
Kincaid John F.
Miller Philip
Amgen Inc.
Gowling Lafleur Henderson Llp
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