C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/12 (2006.01) A61K 31/551 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2392057
Provided are calcium salts of a 1,5-benzodiazepine derivative represented by the following formula (I): (see formula I) (wherein, R1 represents a lower alkyl group, R2 represents a phenyl or cyclohexyl group, and Y represents a single bond or a lower alkylene group); a process for preparing the salts; and drugs containing the same as the active ingredient. The compounds exhibit a potent inhibitory activity against the secretion of gastric acid and potent antagonism against gastrin and/or CCK-B receptor.
Cette invention concerne des sels de calcium de dérivés de 1,5-benzodiazépine représentés par la formule générale (I) (dans laquelle R1 est un alkyle inférieur, R2 est un phényle ou un cyclohexyle, et Y représente une liaison unique ou un alkylène inférieur) ainsi qu'un procédé de fabrication de ces sels et des médicaments renfermant lesdits sels en tant que principe actif. Ces sels présentent une activité inhibitrice puissante contre la sécrétion d'acide hypochlorique gastrique et un antagonisme puissant contre le récepteur CCK-B/gastrine.
Kawase Nobuo
Maeda Kiyoto
Miura Naoyoshi
Murata Masakazu
Shinozaki Katsuo
Gowling Lafleur Henderson Llp
Zeria Pharmaceutical Co. Ltd.
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