C - Chemistry – Metallurgy – 09 – B
Patent
C - Chemistry, Metallurgy
09
B
C09B 33/04 (2006.01) C07D 273/00 (2006.01) C07D 273/08 (2006.01) C07D 413/14 (2006.01) G01N 33/52 (2006.01) G01N 33/84 (2006.01)
Patent
CA 2212466
Diana-18-crown-6 compounds of the formula I: (see formula I) wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: (see formula II) R1, R2, R3, R4 and R5 are independently selected from hydrogen, halo, cyano, nitro, (C1-C6) alkyl, (C2-C8) acyl, acetamido, mercapto, alkyl or arylsulfonyl, trifluoromethyl, aryl, and substituted aryl wherein the aryl moiety is selected from phenyl and naphthyl and the aryl substituent is selected from halo, cyano, nitro, (C1-C6) alkyl, (C2-C8) acyl, phenyl, acetamido, mercapto, alkyl or arylsulfonyl and trifluoromethyl; provided that when R1, R2 , R3 and R5 are hydrogen and X is phenol, R4 is not nitro; and provided that when X is phenol and R5 is hydrogen, R1 (or R2) and R4 are not both nitro. Compounds of the above formula are useful as chromoionophores for the detection of calcium ions in solution or dry assays, but are of particular advantage when used in dry, thin-film multilayer analytical elements.
Logan Margaret Elizabeth
Messing Calvin Roman
Weber Wayne Woodrow II
Gowling Lafleur Henderson Llp
Johnson & Johnson Clinical Diagnositics Inc.
Ortho-Clinical Diagnostics Inc.
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