Calibration method and apparatus for optical-response...

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G01N 21/84 (2006.01) G01N 21/27 (2006.01)

Patent

CA 1252306

CALIBRATION METHOD AND APPARATUS FOR OPTICAL-RESPONSE TISSUE-EXAMINATION INSTRUMENT ABSTRACT OF THE DISCLOSURE A method and apparatus for calibrating optical-response tissue-examination apparatus, and for operating the apparatus as calibrated, in which a novel calibration device is coupled between the sending and receiving components of the optical-response equipment and the equipment is then run through a test cycle of its operation with the calibration device in place and in effect constituting part of the system, to thereby project selected light spectra into the calibration device and receive such light as it emerges from the calibration device. The calibration device provides known, standardized light-transfer characteristics (diffusion and attenuation) which condition the detected emergent light energy in a known and precisely repeatable manner, whereby such conditioned light energy may be used to analytically characterize the optical response apparatus itself. In preferred embodiments, the calibration device incorporates selectively changeable media samples disposed across the path of light travel through the calibration device, whereby the emergent light energy may also be particularly characterized in terms of the known effects on light transfer caused by the selected media. Two or more such media may be utilized so that the emergent light characterized by each different media may be mutually compared, to thereby establish calibration constants for the overall optical capabilities of the optical-response apparatus under calibration. Thus, in subsequent operation of the calibrated apparatus, during actual tissue examination, the calibration constants so determined may be used to modify nominal tissue-examination data and convert it into intrinsically accurate form which may be directly compared on a meaningful quantified basis to any other similarly calibrated tissue-examination apparatus.

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