Calmodulin-binding peptides that reduce cell proliferation...

Details Calmodulin-binding peptides that reduce cell proliferation... Calmodulin-binding peptides that reduce cell proliferation...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61L 31/16 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2697252

The invention relates to an isolated peptide comprising all or part of the amino acid sequence: GGAEFSARSR KRKANVTVFL QD (SEQ ID NO: 2), wherein the peptide reduces cell proliferation. The invention also includes variants, such as SEQ ID NO:3-5 and fragments of at least 5 amino acids of SEQ ID NO:2-5 that reduce cell proliferation. The peptides are useful for treating cancer and diseases characterized by smooth muscle proliferation, such as restenosis.

L'invention porte sur un peptide isolé comprenant tout ou partie de la séquence d'acides aminés : GGAEFSARSR KRKANVTVFL (SEQ ID NO : 2), le peptide réduisant la prolifération cellulaire. L'invention porte également sur des variantes, tels que SEQ ID NO : 3-5 et des fragments d'au moins 5 acides aminés de SEQ ID NO : 2-5 qui réduisent la prolifération cellulaire. Les peptides sont utiles pour traiter le cancer et des maladies caractérisées par une prolifération du muscle lisse, telles que la resténose.

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