Calpain-inhibiting peptide analogs of the kininogen heavy chain

Details Calpain-inhibiting peptide analogs of the kininogen heavy chain Calpain-inhibiting peptide analogs of the kininogen heavy chain

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2111870

2111870 9300105 PCTABS00019 Synthetic peptide analogs of human kininogen are provided which are conformationally restricted by means of intramolecular bonding. The peptides mimic the biological activity of human kininogen by inhibiting the activity of the biologically significant protease, calpain. The peptides are designed by means of an equilibrium conformational model of the kininogen heavy chain.

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