Calycosin and analogs thereof for the treatment of estrogen...

A - Human Necessities – 61 – K

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A61K 31/352 (2006.01) A61K 36/481 (2006.01) A61P 9/00 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C07D 311/36 (2006.01) C07D 311/40 (2006.01)

Patent

CA 2721191

Estrogenic compositions comprising calycosin and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treat-ment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodi-ments, the methods include treatment or prevention of osteoporosis.

Linvention concerne des compositions oestrogéniques contenant de la calycosine et ses analogues. Linvention concerne également des méthodes dutilisation de ces extraits pour obtenir un effet oestrogénique, en particulier chez un humain, une femme notamment. Dans certains modes de réalisation, ces méthodes comprennent le traitement des symptômes climatériques. Dans dautres modes de réalisation, ces méthodes comprennent le traitement du cancer à récepteurs doestrogènes positifs, tel que le cancer du sein sensible aux oestrogènes. Dans dautres modes de réalisation encore, ces méthodes comprennent le traitement ou la prévention de lostéoporose.

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