Camello gene family and uses thereof

Details Camello gene family and uses thereof Camello gene family and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2376142

The present invention provides a purified and isolated nucleic acid encoding a camello protein. The present invention also provides a vector comprising nucleic acid encoding camello, a host cell transformed with the vector and a method for producing recombinant camello protein. In addition, the present invention also provides a purified camello protein. Also provided by the present invention is nucleic acid probes and mixtures thereof specific for camello nucleic acid and antibodies immunoreactive with camello. The present invention also provides a method for screening for agents which bind to the camello protein and the nucleic acid encoding the camello. Finally, the present invention provides a non-human, transgenic model for camello expression.

La présente invention concerne un acide nucléique isolé et purifié codant une protéine camello. Elle concerne aussi un vecteur comprenant un acide nucléique codant la protéine camello, une cellule hôte transformée par le vecteur et une méthode de production d'une protéine camello recombinante. L'invention concerne également une protéine camello purifiée, des sondes d'acide nucléique et leurs mélanges spécifiques pour l'acide nucléique camello, et des anticorps capables de réaction immunitaire en présence de camello. L'invention concerne en outre des méthodes de criblage permettant de déceler des agents pouvant se lier à la protéine camello et l'acide nucléique codant la protéine camello. Elle concerne enfin un modèle transgénique non humain capable d'exprimer camello.

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