Camptothecin analogs as potent inhibitors of human...

Details Camptothecin analogs as potent inhibitors of human... Camptothecin analogs as potent inhibitors of human...

C - Chemistry, Metallurgy

12

N

C12N 9/90 (2006.01) A61K 31/47 (2006.01) C07D 471/04 (2006.01) C07D 491/14 (2006.01) C07D 491/20 (2006.01) C07D 491/22 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2067491

2067491 9105556 PCTABS00005 A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.

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