C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/4741 (2006.01) A61K 31/4745 (2006.01)
Patent
CA 2396030
.beta.-Alanine esters of camptothecin compounds having the structure: Image which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I- DNA cleavable complex.
L'invention porte sur des composés d'esters .beta.-Alanine de camptothécine qui sont des composés antitumoraux efficaces. Ces composés inhibent l'enzyme topoisomérase I et peuvent alkyler l'ADN du complexe associé clivable de l'ADN de la topoisomérase I.
Balasubramanian Neelakantan
Manikumar Govindarajan
Vyas Dolatrai
Wall Monroe E.
Wani Mansukh C.
Bristol-Myers Squibb Company
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Research Triangle Institute
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