Camptothecin-binding moiety conjugates

Details Camptothecin-binding moiety conjugates Camptothecin-binding moiety conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/14 (2006.01) C07K 16/18 (2006.01) C07K 16/20 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2647130

The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.

L'invention concerne des conjugués thérapeutiques présentant une capacité améliorée de cibler diverses cellules malades contenant un groupement de ciblage (tel qu'un anticorps ou un fragment d'anticorps), un lieur et une camptothécine à titre de groupement thérapeutique. L'invention concerne en outre des procédés permettant de fabriquer et d'utiliser lesdits conjugués.

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