Camptothecin-binding moiety conjugates

Details Camptothecin-binding moiety conjugates Camptothecin-binding moiety conjugates

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2713933

The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.

Cette invention concerne des conjugués thérapeutiques dotés dune capacité améliorée à cibler différentes cellules malades contenant une fraction de ciblage (anticorps ou fragment danticorps par exemple), un lieur et une camptothécine comme fraction thérapeutique ; linvention concerne par ailleurs un procédé de fabrication et dutilisation desdits conjugués.

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