Camptothecin-carboxylate formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4745 (2006.01) A61K 9/127 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2489555

The present invention relates to compositions, particularly colloidal nanoaggregates comprising the carboxylate form of a campothecin drug or a derivative thereof associated with at least one organic cationic molecule, which has a positive net charge. The composition or nanoaggregate may be present as an emulsion, droplet, mincelle, liposome, nanoparticle or nanocapsule.

L'invention concerne des compositions, notamment des nanoagrégats colloïdaux contenant la forme carboxylate d'une camptothécine ou d'un dérivé de celle-ci, en association avec au moins une molécule cationique organique ayant une charge nette positive. La composition ou le nanoagrégat peut se présenter sous forme d'émulsion, de goutte, de micelle, de liposome, de nanoparticule ou de nanocapsule.

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