Camptothecin compounds with a sulfhydryl group

Details Camptothecin compounds with a sulfhydryl group Camptothecin compounds with a sulfhydryl group

A - Human Necessities

61

K

A61K 33/44 (2006.01) A61K 31/4745 (2006.01) A61K 47/48 (2006.01) C07D 491/22 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2428802

Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.

L'invention concerne des composés de camptothécine efficaces en tant que composés antitumoraux. Ces conjugués inhibent l'enzyme topoisomérase I et améliorent la stabilité du complexe associé clivable de l'ADN de la topoisomérase I.

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