Camptothecin derivatives

Details Camptothecin derivatives Camptothecin derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2434747

(20S)esters of camptothecin analogs are provided. The compounds are (20S) esters of an oxyalkanoic acid and camptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the camptothecin ring. The compounds are useful for treating cancer.

L'invention concerne des esters (20<i>S</i>) d'analogues de camptothécine. Les composés sont des esters (20<i>S</i>) d'un acide oxyalcanoïque et de camptothécine éventuellement substituée aux positions 7, 9, 10, 11, et 12 du noyau de ladite camptothécine. Ces composés sont utilisés pour traiter le cancer.

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