Camptothecin derivatives

Details Camptothecin derivatives Camptothecin derivatives

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/715 (2006.01) A61K 38/14 (2006.01) A61K 47/48 (2006.01) C07D 491/22 (2006.01) C07K 5/065 (2006.01) C07K 5/103 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2182244

The present invention is directed to a camptothecin derivative comprising a compound of the formula [I]: (see formula (I) wherein R1 is a substituted or unsubstituted lower alkyl group, X1 is a group of the formula: -NHR2 (R2 is a hydrogen atom or a lower alkyl group) or a group of -OH, and Alk is a straight chain or branched chain alkylene group having optionally an oxygen atom in the chain thereof, bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects unlike conventional anticancer agents, and hence, these compounds are extremely useful as a medicament.

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