Camptothecin derivatives and process for preparing same

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

167/211, 260/246

C07D 491/22 (2006.01) C07F 9/65 (1985.01)

Patent

CA 1235415

Abstract: New camptothecin derivatives possessing high anti-tumor activity with slight toxicity, represented by the general formula: Image (I) wherein R1 is a hydrogen atom, a halogen atom or an alkyl group with 1-4 carbon atoms and X is a chlorine atom or -NR2R3 where R2 and R3 are the same or different and each represents a hydrogen atom, a substituted or unsubstituted alkyl group with 1-4 carbon atoms or a substituted or unsubsti- tuted carbocyclic or heterocyclic group, with the proviso that when both R2 and R3 are the substituted or unsubstituted alkyl groups, they may be combined together with the nitrogen atom, to which they are bonded, to form a heterocyclic ring which may be interrupted with -O-, -S- and/or? N-R4 in which R4 is a hydrogen atom, a substituted or unsubstituted alkyl group with 1-4 carbon atoms or a substituted or unsubstituted phenyl group and wherein the grouping -O-CO-X is bonded to a carbon atom located in any of the 9-, 10- and 11-positions in the ring A of camptothecin, as well as an ammonium salt or an alkali metal salt thereof. These new camptothecin derivatives are prepared by reacting a 7-R1-camptothecin derivative having a hydroxyl group in any of the 9-, 10- and 11-positions on the ring A thereof with phosgen and then reacting, if necessary, the resultant 7-R1-camptothecin derivative having a chlorocarbonyloxy group in the same position on the ring A thereof with an amine HNR2R3 or by reacting a 7-R1-camptothecin derivative having a hydroxyl group in any of the 9-, 10- and 11-positions on the ring A thereof with a carbamoyl chloride C1-CONR2R3. - 1 -

458228

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Camptothecin derivatives and process for preparing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Camptothecin derivatives and process for preparing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Camptothecin derivatives and process for preparing same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1283495

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.