C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/435 (2006.01)
Patent
CA 2253914
The present invention relates to the isolation or the semisynthesis of novel alkaloids of formula (I) present in different parts of Mappia foetida as well as the pharmaceutical use thereof and the use thereof as novel syntones for the preparation of compounds with antitumor and antiviral activities; the same products are novel syntones for the preparation of novel analogues of camptothecin and of Foetidines I and II. The particular water solubility of these novel compounds is of remarkable importance as it allows the parenteral administration without requiring derivatization.
L'invention concerne l'isolement ou la semi-synthèse de nouveaux alcaloïdes de formule (I) présents dans différentes parties de Mappia foetida ainsi que l'utilisation pharmaceutique de ceux-ci en tant que syntones nouveaux pour la préparation de composés à activités antitumorale et antivirale. Lesdits produits sont des nouveaux syntones pour la préparation de nouveaux analogues de camptothécine et de foetidines I et II. L'hydrosolubilité particulière de ces nouveaux composés revêt une grande importance car elle permet l'administration parentérale sans qu'une dérivatisation soit nécessaire.
Bombardelli Ezio
Verotta Luisella
Indena S.p.a.
Kirby Eades Gale Baker
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