C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12P 19/18 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2360205
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an .alpha.2,3- and an .alpha.2,8- activity. A .beta.1,4-GalNAc transferase and a .beta.1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.
La présente invention concerne des glycosyltransférases procaryotes, y-compris une sialyltransférase bifonctionnelle présentant une activité .alpha.2,3- ainsi qu'une activité .alpha.2,8-. L'invention concerne également une transférase .beta.1,4-GalNAc et une glycosyltransférase en .beta.1,3-, ainsi que d'autres glycosyltransférases et enzymes impliqués dans la synthèse du lipooligosaccharide (LOS). Ces glycosyltransférases peuvent provenir notamment de l'espèce Campylobacter, y compris C. jejuni. Pour d'autres réalisations, l'invention concerne des acides nucléiques codant pour les glycosyltransférases, ainsi que des vecteurs d'expression et cellules hôtes permettant l'expression de ces glycosyltransférases.
Gilbert Michel
Wakarchuk Warren W.
Fetherstonhaugh & Co.
National Research Council Of Canada
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