Campylobacter glycosyltransferases for biosynthesis of...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12P 19/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2441570

This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an .alpha.2,3- and an .alpha.2,8- activity. A .beta.1,4-GalNAc transferase and a .beta.1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

Cette invention concerne des glycosyltransférases prokaryotiques, dont une sialyltransférase bifonctionnelle qui possède une activité à la fois .alpha.2,3 et .alpha.2,8. L'invention concerne également une transférase .beta.1,4-GalNAc et une .beta.1,3-galactosyltransférase, ainsi que d'autres glycosyltransférases et enzymes intervenant dans la synthèse de lipo-oligosaccharide (LOS). Les glycosyltransférases s'obtiennent, par exemple, à partir d'espèces de <i>Campylobacter</i>, y compris <i>C. jejuni</i>. Dans d'autres modes de réalisation, l'invention concerne des acides nucléiques qui codent pour les glycotransférases, ainsi que des vecteurs d'expression et des cellules hôtes exprimant les glycosyltransférases.

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