C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/106 (2006.01) A61K 39/40 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) C12N 1/20 (2006.01) C12N 15/70 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2167691
The present invention provides an isolated nucleic acid encoding an approximately 26 kilodalton antigen, PEB1A, of Campylobacter jejuni, or an antigenic fiagment thereof, wherein the antigen is associated with diarrheal disease. The present invention also provides methods of detecting the presence of a Campylobacter jejuni strain possessing the PEB1A antigen in a subject. Vaccines and treatment for C. jejuni infection are provided, as is a mutant C. jejuni not expressing a functional PEB1A antigen.
L'invention concerne un acide nucléique isolé qui code un antigène d'environ 26 kilodaltons, PEB1A, de Campylobacter jejuni, ou un fragment antigénique de celui-ci; cet antigène est associé à des troubles diarrhéiques. L'invention présente également des procédés de détection de la présence chez un sujet d'une souche de Campylobacter jejuni possédant l'antigène PEB1A. Des vaccins et des traitements contre les infections à C. jejuni sont décrits, ainsi qu'un C. jejuni mutant qui n'exprime pas un antigène PEB1A fonctionnel.
Blaser Martin J.
Pei Zhiheng
Enteric Research Laboratories Inc.
Riches Mckenzie & Herbert Llp
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