Cancer antigen mage-a9 and uses thereof

Details Cancer antigen mage-a9 and uses thereof Cancer antigen mage-a9 and uses thereof

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2630023

The present invention relates to the detection of MAGE-A9 in a biological sample and to the diagnosis, prevention and treatment of MAGE-A9-associated aberrant cell growth, through the targeting of the MAGE-A9 polypeptide and/or polynucleotide. Diagnosis is accomplished by examining or monitoring cells for perturbations in MAGE-A9 expression. Prevention and treatment are accomplished by administering to a subject MAGE-A9 as a protein or a fragment thereof or under form of a DNA expression vector, as well as by administering to a subject a MAGE-A9 gene product-binding agent. Compositions and commercial kits are also provided.

La présente invention concerne la détection de MAGE-A9 dans un échantillon biologique ainsi que le diagnostic, la prévention et le traitement d'une croissance cellulaire aberrante associée à MAGE-A9 par le ciblage du polypeptide et/ou du polynucléotide MAGE-A9. Le diagnostic est accompli par examen ou surveillance des cellules à la recherche de perturbations dans l'expression de MAGE-A9. La prévention et le traitement sont réalisés par administration à un sujet du MAGE-A9 sous forme d'une protéine ou d'un fragment de celle-ci ou sous forme d'un vecteur d'expression de l'ADN, de même que par administration au sujet d'un agent de liaison au produit génique MAGE-A9. L'invention concerne, également, des compositions et des kits commerciaux.

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