Cancer antigen-specific t-cell receptor gene, peptide...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2679045

Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or treatment of cancer using the nucleotide sequence or the amino acid sequence; and a chip, a primer set, a kit, an apparatus and the like for use in the detection of cancer, each of which comprises the nucleotide sequence or the amino acid sequence.

L'invention porte sur : une séquence nucléotidique et une séquence d'acides aminés pour la région CDR3 du gène de récepteur de lymphocytes T (TCR) des lymphocytes T cytotoxiques spécifiques de WT1 (CTL) pour la protéine WT1 ; sur un procédé pour la détection ou le traitement de cancer à l'aide de la séquence nucléotidique ou de la séquence d'acides aminés ; et sur une puce, un ensemble d'amorces, un coffret, un appareil et similaires pour une utilisation dans la détection du cancer, dont chacun comprend la séquence nucléotidique ou la séquence d'acides aminés.

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