Cancer associated araf1 protein kinase and its uses

Details Cancer associated araf1 protein kinase and its uses Cancer associated araf1 protein kinase and its uses

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C12N 15/11 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2478924

Detection of expression of the provided protein kinase in cancers is useful as a diagnostic, for determining the effectiveness of drugs, and determining patient prognosis. The encoded polypeptides further provide targets for screening pharmaceutical agents effective in inhibiting the growth or metastasis of tumour cells. The present invention further provides methods and compositions relating to agents that specifically bind to Araf1 for treatment and visualization of tumours in patients.

Selon l'invention, la détection de l'expression d'une protéine kinase dans les cancers est utile pour la réalisation d'un diagnostic, pour déterminer l'efficacité de médicaments et pour déterminer un pronostic d'un patient. Les polypeptides codés fournissent en outre des cibles pour le criblage d'agents pharmaceutiques efficaces pour inhiber la croissance ou la métastase de cellules tumorales. La présente invention concerne également des méthodes et des compositions associées à des agents se liant spécifiquement à Araf1 pour le traitement et la visualisation de tumeurs chez des patients.

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