Cancer associated protein kinases and their uses

Details Cancer associated protein kinases and their uses Cancer associated protein kinases and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/00 (2006.01) A61K 38/45 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2480635

Detection of expression of the provided protein kinase in cancers is useful as a diagnostic, for determining the effectiveness of drugs, and determining patient prognosis. The encoded polypeptides further provide a target for screening pharmaceutical agents effective in inhibiting the growth or metastasis of tumor cells. The present invention further provides methods and compositions relating to agents that specifically bind to HSM801163, PCTK3, PFTK1, CRK7, PRKCN, CIT, STK6, PDK1, PAK4, ITK, BMX, PRKCM, NEK6 or PDPK1 for treatment and visualization of tumors in patients.

L'invention concerne la détection de l'expression d'une protéine kinase dans les cancers pour établir un diagnostic, déterminer l'efficacité de médicaments et faire un pronostic sur un patient. Les polypeptides codées fournissent une cible pour cribler des substances pharmaceutiques efficaces dans l'inhibition de la croissance ou de la formation de métastases de cellules tumorales. La présente invention porte également sur des procédés et des compositions concernant des agents qui se lient de manière spécifique à HSM801163, PCTK3, PFTK1, CRK7, PRKCN, CIT, STK6, PDK1, PAK4, ITK, BMX, PRKCM, NEK6 ou PDPK1 pour traiter et visualiser des tumeurs chez des patients.

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