C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) A61K 49/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2480664
Detection of expression of the provided phosphatases in cancers is useful as a diagnostic, for determining the effectiveness of drugs, and for determining patient prognosis. The encoded polypeptides further provide a target for screening pharmaceutical agents effective in inhibiting the growth or metastasis of tumor cells. The present invention further provides methods and compositions relating to agents that specifically bind to MKPX, PTP4A1, PTPN7, FEM-2, DKFZP566K0524 or FLJ20313 for treatment and visualization of tumors in patients.
La détection de l'expression des phosphatases faisant l'objet de l'invention dans des cancers peut servir de diagnostic, et permettre de déterminer l'efficacité de médicaments ainsi que d'établir le pronostic d'un patient. Les polypeptides codés constituent en outre une cible pour cribler des agents pharmaceutiques inhibant efficacement la croissance ou la métastase de cellules tumorales. Cette invention concerne en outre des procédés et des compositions concernant des agents qui se lient de manière spécifique à MKPX, PTP4A1, PTPN7, FEM-2, DKFZP566K0524 ou FLJ20313, permettant de traiter et de visualiser des tumeurs chez des patients.
Qlt Inc.
Smart & Biggar
LandOfFree
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