Cancer cell targeting using nanoparticles

Details Cancer cell targeting using nanoparticles Cancer cell targeting using nanoparticles

C - Chemistry, Metallurgy

07

C

C07C 275/04 (2006.01) A61K 9/51 (2006.01) A61K 31/713 (2006.01) A61K 47/18 (2006.01) A61K 47/34 (2006.01) A61P 35/00 (2006.01) C08G 63/664 (2006.01) C08G 63/91 (2006.01) C08G 65/333 (2006.01)

Patent

CA 2702305

The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

La présente invention concerne généralement des polymères et des macromolécules, en particulier, des polymères utiles dans des particules telles que des nanoparticules. Un aspect de l'invention concerne un procédé de développement de nanoparticules avec des propriétés souhaitées. Dans un ensemble de modes de réalisation, le procédé comprend la production de pharmacothèques de nanoparticules ayant des propriétés hautement régulées, qui peuvent être formées en mélangeant ensemble deux macromolécules ou plus en différents rapports. Une ou plusieurs des macromolécules peuvent être un conjugué polymère d'une fraction à un polymère biocompatible. Dans certains cas, la nanoparticule peut contenir un médicament. D'autres aspects de l'invention concernent des procédés utilisant des pharmacothèques de nanoparticules.

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