A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/277 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2708006
The present invention relates to targets of loss of imprinting (LOI) affected IGF2 gene products in pre-malignant tissues, where methods of inhibiting those targets, including IGFR1, are disclosed to prevent tumor development in subjects at risk for developing colorectal cancer (CRC). The present invention also relates to methods of identifying increased risk in developing CRC in a subject, including methods of assessing the efficacy of a chemotherapeutic regimen. Further, the present invention relates to methods for identifying anti-neoplastic agents.
La présente invention concerne des cibles de perte d'empreinte de produits de gène IGF2 affectés dans des tissus pré-malins. L'invention concerne également des procédés d'inhibition de ces cibles, incluant IGFRl, afin de prévenir le développement de tumeur chez des sujets présentant un risque de développement d'un cancer colorectal (CCR). La présente invention concerne en outre des procédés d'identification de risque accru en matière de développement de CCR chez un sujet, incluant des procédés d'évaluation de l'efficacité d'un régime chimiothérapeutique. En outre, la présente invention concerne des procédés destinés à identifier des agents anti-néoplastiques.
Feinberg Andrew P.
Ko Minoru S. H.
Levchenko Andre
Longo Dan L.
Mbm Intellectual Property Law Llp
The Government Of The United States Of America As Represented By
The Johns Hopkins University
LandOfFree
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