Cancer detection reagents and uses in pathology and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2646194

Cancer detection reagents have been identified through comparison of cancer mRNAs with the transcriptome of healthy cells. These cancer detection reagents may be used for a variety of purposes including diagnostics and targeted destruction of cancer cells. In diagnostic applications, peripheral blood or other tissue samples from a subject may be analyzed to generate a cancer profile for that subject. That profile may then be used to guide cancer treatment with known agents. It may also be used to generate agents capable of killing the subject's cancer cells in a targeted manner. These agents may include antibodies and siRNA, RNAi, or antisense RNA.

L'invention concerne des réactifs de détection du cancer identifiés par comparaison d'ARNm de cancer avec le transcriptome de cellules saines. Ces réactifs de détection peuvent être utilisés à des fins diverses, notamment dans le diagnostic et la destruction ciblée des cellules cancéreuses. Dans les applications diagnostiques, le sang périphérique ou d'autres échantillons tissulaires prélevés sur un sujet peuvent être analysés pour produire le profil de cancer du sujet. Ce profil peut ensuite être utilisé pour guider le traitement du cancer au moyen d'agents connus. Ce profil peut également être utilisé pour produire des agents aptes à détruire les cellules cancéreuses du sujet de manière ciblée. Ces agents peuvent comprendre des anticorps et des petits ARN interférents, des interférences ARN ou des ARN antisens.

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