C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2681144
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
L'invention concerne un procédé de production d'anticorps ayant une action sur une maladie cancéreuse, mettant en AEuvre un nouveau paradigme de criblage. La ségrégation des anticorps anticancéreux par la cytotoxicité des cellules cancéreuses servant de point terminal permet de produire des anticorps anticancéreux à des fins thérapeutiques et diagnostiques. Ces anticorps peuvent être utilisés dans la stadification et le diagnostic d'un cancer, ainsi que dans le traitement des tumeurs primaires et des métastases tumorales. Les anticorps anticancéreux selon l'invention peuvent être conjugués à des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.
Cechetto Lisa M.
Findlay Helen P.
Hahn Susan E.
Young David S.f.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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