Cancer gene determination and therapeutic screening using...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2411601

Processes for assaying potential antitumor agents based on their modulation of the expression of specified genes, or sets, of suspected cancer cell genes are disclosed, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, or sets of genes. Also disclosed are methods for determining functionally related genes, or gene sets, as well as methods for treating cancer based on targeting expression products of such genes, or gene sets, and determining genes involved in the cancerous process.

La présente invention concerne des processus permettant d'analyser des agents antitumoraux potentiels fondés sur leur modulation de l'expression de gènes spécifiés, ou d'ensembles de gènes de cellule cancéreuse suspectés, ainsi que des techniques permettant d'établir un diagnostic de cancer, ou de cancer potentiel, d'état liés à l'expression ou à des schémas d'expression de ces gènes ou de ces ensembles de gènes. Cette invention concerne aussi des techniques permettant de déterminer des gènes ou des ensembles de gènes liés fonctionnellement, de même que des techniques de traitement de cancer fondées sur des produits d'expression de ciblage de ces gènes ou de ces ensembles de gènes, et qui déterminent des gènes impliqués dans un processus cancéreux.

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