Cancer gene therapeutic drug

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 31/409 (2006.01) A61K 33/26 (2006.01) A61K 35/12 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2542335

An oncogene therapeutic drug which comprises a combination of a virus for an immunological treatment to be administered for inducing a CTL reaction within the living bodywith a carrier cell having been infected with an oncolytic virus before administration so as to treat a tumor cell with the virus within the living body. As the carrier cell, use can be made of, for example, an A549 cell. As the virus for an immunological treatment, use can be made of, for example, a non-proliferative adenovirus having been inactivated by UV irradiation. As the oncolytic virus, use can be made of, for example, a proliferative adenovirus having a tumor-specific promoter.

L'invention concerne un médicament de traitement anticancéreux comprenant une association constituée d'un virus servant à effectuer un traitement immunologique et destiné à être administré pour induire une réaction CTL dans un corps vivant, ainsi que d'une cellule vectrice qui a été infectée par un virus oncolytique avant d'être administrée pour traiter une cellule tumorale avec ledit virus dans le corps vivant. Une cellule de type A549 peut par exemple être utilisée en tant que cellule vectrice. Un adénovirus non prolifératif ayant été inactivé par un rayonnement ultraviolet peut par exemple être employé en tant que virus de traitement immunologique. Un adénovirus prolifératif comportant un promoteur à spécificité tumorale peut par exemple être utilisé en tant que virus oncolytique.

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