A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2278678
The present invention relates to improved semi-allogeneic immunogenic cells which act to stimulate and induce an immunological response when administered to an individual. In particular, it relates to cells which express both allogeneic and syngeneic MHC determinants and which also express at least one antigen recognized by T lymphocytes. The invention is also directed to methods of inducing an immune response and methods of treating tumors by administering the semi-allogeneic immunogenic cells to an individual.
La présente invention concerne des cellules semi-allogéniques immunogènes qui, lorsqu'elles sont administrées à un patient, stimulent et provoquent une réponse immunitaire. L'invention concerne notamment des cellules exprimant à la fois des déterminants du CMH allogéniques et syngéniques et exprimant également au moins un antigène reconnu par les lymphocytes T. Enfin, l'invention a pour objet des procédés destinés à provoquer une réponse immunitaire ainsi que des procédés de traitement des tumeurs qui consistent à administrer à un individu des cellules semi-allogéniques immunogènes.
Cohen Edward P.
Mcfadden Fincham
Research Corporation Technologies Inc.
LandOfFree
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