C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/32 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/82 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2478607
Cancer/linked gene sequences, and derved amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosis using the gene sequences.
La présente invention concerne des séquences de gènes liés au cancer, des séquences d'acides aminés dérivées ainsi que des procédés destinés à analyser des agents antitumoraux potentiels sur la base de leur modulation de l'expression de ces gènes liés au cancer. Cette invention concerne également des anticorps qui réagissent avec les polypeptides de cette invention, ainsi que des méthodes d'utilisation de ces anticorps pour traiter des états cancéreux, lesquelles méthodes consistent par exemple à utiliser l'anticorps pour cibler les cellules cancéreuses in vivo afin que des agents thérapeutiques soient libérés dans ces cellules. Cette invention concerne également des méthodes de diagnostic utilisant les séquences de gènes susmentionnées.
Ebner Reinhard
Strovel Jeffrey W.
Young Paul E.
Avalon Pharmaceuticals
Smart & Biggar
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