Cancer-linked gene as target for chemotherapy

Details Cancer-linked gene as target for chemotherapy Cancer-linked gene as target for chemotherapy

C - Chemistry, Metallurgy

07

K

C07K 16/32 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12Q 1/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2478593

Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.

L'invention porte sur des séquences de gènes liés au cancer et sur des séquences d'acide aminé dérivé, ainsi que sur des procédés de dosage d'agents anti-tumeurs potentiels en fonction de leur modulation de l'expression de ces gènes liés au cancer. L'invention se rapporte aussi à des anticorps qui réagissent avec les polypeptides et à des procédés d'utilisation de ces anticorps afin de traiter des conditions cancéreuses, tels que l'utilisation de l'anticorps afin de cibler les cellules cancéreuses in vivo de manière administrer des agents thérapeutiques. L'invention concerne également des procédés de diagnostic au moyen de ces séquences de gènes.

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