C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2478604
Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosis using the gene sequences.
L'invention concerne des séquences géniques associées au cancer et des séquences d'acides aminés dérivées, ainsi que des procédés d'analyse d'agents antitumoraux potentiels en fonction de leur modulation de l'expression de ces gènes associés au cancer. L'invention concerne également des anticorps qui réagissent avec les polypeptides de l'invention, et des procédés d'utilisation desdits anticorps afin de traiter des états cancéreux, par exemple par utilisation de l'anticorps afin de cibler des cellules cancéreuses in vivo pour y administrer des agents thérapeutiques. L'invention concerne en outre des méthodes diagnostiques mettant en oeuvre lesdites séquences géniques.
Ebner Reinhard
Weaver Zoe
Young Paul E.
Avalon Pharmaceuticals
Smart & Biggar
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