C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2485983
Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
L'invention concerne des séquences de gènes liés au cancer, des séquences d'amino-acides dérivées, ainsi que des procédés permettant d'analyser des agents antitumoraux potentiels en fonction de leur modulation de l'expression desdits gènes liés au cancer. L'invention concerne également des anticorps qui réagissent avec les polypeptides faisant l'objet de l'invention et des procédés d'utilisation de ces anticorps pour traiter des états cancéreux, par exemple pour cibler des cellules cancéreuses <i>in vivo </i>afin de permettre l'apport à ces cellules d'agents thérapeutiques. L'invention concerne également des procédés de diagnostic faisant appel à ces séquences géniques.
Ebner Reinhard
Horrigan Stephen K.
Avalon Pharmaceuticals
Smart & Biggar
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