C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2488629
Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
L'invention concerne des séquences de gènes liés au cancer, des séquences d'acides aminés dérivées, ainsi que des procédés destinés à analyser les agents antitumoraux potentiels sur la base de la modulation d'expression qu'ils exercent sur les gènes liés au cancer. Par ailleurs, l'invention concerne des anticorps qui réagissent avec les polypeptides de l'invention ainsi que des méthodes d'utilisation de ces anticorps pour traiter des états cancéreux ; ces méthodes consistant à utiliser l'anticorps pour cibler les cellules cancéreuses cibles in vivo et y introduire des agents thérapeutiques. L'invention concerne en outre des méthodes diagnostiques mettant en oeuvre les séquences de gènes susmentionnées.
Ebner Reinhard
Rick Jennifer A.
Avalon Pharmaceuticals Inc
Smart & Biggar
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