Cancer-linked gene as target for chemotherapy

Details Cancer-linked gene as target for chemotherapy Cancer-linked gene as target for chemotherapy

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2486060

Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.

L'invention concerne des séquences de gènes liés au cancer, des séquences d'acides aminés dérivées, ainsi que des procédés destinés à analyser des agents antitumoraux potentiels sur la base de la modulation d'expression qu'ils exercent sur ces gènes liés au cancer. Cette invention concerne également des anticorps qui réagissent avec les polypeptides de l'invention, ainsi que des méthodes d'utilisation de ces anticorps pour traiter des états cancéreux, lesquelles méthodes consistent par exemple à utiliser l'anticorps pour cibler les cellules cancéreuses in vivo afin d'induire la libération des agents thérapeutiques dans ces cellules. Par ailleurs, l'invention concerne des méthodes de diagnostic qui font intervenir les séquences de gènes précitées.

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