C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2489198
Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
L'invention concerne des séquences de gènes liés au cancer et des séquences d'acides aminés dérivées, ainsi que des procédés permettant d'analyser des agents antitumoraux potentiels en fonction de leur pouvoir de modulation de l'expression des gènes en question. L'invention concerne également des anticorps qui réagissent avec les polypeptides selon l'invention, ainsi que des procédés d'utilisation desdits anticorps pour le traitement d'états cancéreux, par exemple pour le ciblage de cellules cancéreuses in vivo, le but étant de leur administrer des agents thérapeutiques. L'invention concerne enfin des procédés de diagnostic à l'aide desdites séquences de gènes.
Ebner Reinhard
Young Paul E.
Avalon Pharmaceuticals Inc.
Smart & Biggar
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