Cancer marker and monoclonal antibodies specific therefor

Details Cancer marker and monoclonal antibodies specific therefor Cancer marker and monoclonal antibodies specific therefor

C - Chemistry, Metallurgy

12

P

167/37, 530/15.0

C12P 21/08 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2025231

43474 CAN lA ABSTRACT Monoclonal antibodies specific for a cancer marker, as well as hybridoma cell lines producing such antibodies; a method of purifying the marker to an extent sufficient to use the marker for the production of such monoclonal antibodies; the purified marker itself; monoclonal antibodies prepared using the purified marker; and an assay for the marker using the monoclonal antibodies. The marker is one that: (1) exhibits RNA-releasing activity; (2) is detectable in the serum of substantially all patients having either disseminated or localized tumors by means of an assay for such RNA-releasing activity, and (3) exhibits a molecular weight of on the order of 70 kDa.

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