A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/74 (2006.01) A61K 31/715 (2006.01) C12P 19/04 (2006.01)
Patent
CA 2213775
The present invention relates to the technology for inhibiting the cancer metastasis, and is aimed at the provision of a pharmaceutical composition for effectively inhibiting the metastasis of the cancer. A cancer metastasis inhibitor according to the present invention is characterized by containing a sugar chain separated from a surface of a Streptococcus agalactiae Ia type or Ib type as a main ingredient. Since the surface sugar chains of the Streptococcus agalactiae Ia type or Ib type have structures similar to surface sugar chains of the cancer cells, the former surface sugar chains adhere to E-selectin appearing in an intravascular endothelial cell, competitively inhibit the adhesion between intravascular endothelial cells and the cancer cells, and effectively prevent of the metastasis of the cancer, when the sugar chains exist in blood of a patient.
L'invention concerne une composition médicinale inhibant efficacement les métastases cancéreuses, qui comprend une chaîne sucre séparée de la surface de Streptococcus agalactiae de type Ia et/ou de type Ib comme composant principal. Grâce à la ressemblance structurale avec la chaîne sucre de surface de cellules cancéreuses, la chaîne sucre de surface de Streptococcus agalactiae Ia ou de type Ib adhère à la E-sécrétine exprimée dans les cellules endothéliales vasculaires lorsqu'elle est contenue dans le sang d'un patient, et elle inhibe, de façon antagoniste, l'adhérence des cellules endothéliales vasculaires à des cellules cancéreuses, empêchant ansi efficacement les métastases cancéreuses.
Iijima Shinji
Kawase Mitsuo
Miyake Katsuhide
Yamamoto Shin
Yoshida Yasuko
Ngk Insulators Ltd.
Smart & Biggar
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